Laboratory of Synthetic Organic and Medicinal Chemistry
11/03– Great success in Soural group! Sona has been placed 9th (from more than 200 candidates) with her dissertation thesis High-throughput conjugation of drug-like molecules for chemical biology in prestigious Werner Von Siemens Prize this year! Congrats!
02/03– Collaboration within our Department bears fruit again! First-authorship paper for Sona dealing with novel method for preparation of N-substituted 3-hydroxyquinolinones incollaboration with Jan Hlavac group is now online in RSC Advances.Congratulations!
13/01– What is the best way to start the new year? Accepted publication in prestigious Journal of Medicinal Chemistry! Our long-time collaboration with Jagiellonian University in Kraków about imidazopyridine-based 5-HT6 receptor derivatives yielded this perfect piece of work. Congratulation to David for his another first-authored paper. 🙂
23/12– Huge success for Soural group again! The work of Patricia and Bara about copper-free polymer-supported synthesis of triazoles was accepted in Adv. Synth. Catal.! It seems like this year won’t be so bad after all. 🙂
16/12–Hello there after a while! We have some good news to share within the scientific world. It looks like Christmas are coming to Olomouc earlier this year: a very comprehensive and quality study about BTK inhibitors was accepted in Eur. J. Med. Chem. Congratulation to Sona and David! We enjoyed another successful collaboration with our favourite colleagues from LGR very much. 🙂
30/09– Another interesting work dealing with chiral oxazepanes is online in RSC Advances. Congratulation to all authors!
19/09–Our collaboration with Jagiellonian University in Kraków (Poland) bears another sweet fruit! The new work about PDE 4 and 7 inhibitory activity is now online in Eur. J. Med. Chem. Congratulations to David, Veronika and Bara!
01/08– Our new work dealing with SYK inhibitors is now online!Good job from our collaborators in Laboratory of Growth Regulators and congratulation to Sona for her another (shared) first authorship publication!
08/07–Another Dean’s Award competition, another Soural group success!David and Petra have presented their work and won 1st and 2nd place, respectively, in chemistry Ph.D. section. Congratulation to both of you!
18/03– Petra has been nominated as a representative of Palacky University in Jean-Marie Lehn Prize for Chemistry. Fingers crossed!
11/03 – Since today our undergraduate students are not allowed to work in the lab due to the COVID-19 restrictions. 😦 But the health is of course more important! We hope that the situation will get better soon. Stay home, study literature. 🙂
20/01 – 22/01 – The time of the year is here again! We had spent 3 amazing days at traditional team-building event of our Department at Ski Areal Karlov pod Pradedem. Amazing weather and great people, as always. 🙂
16/12 – Another successful collaboration in our group! Petra published another first-authored paper, this time in The Journal of Organic Chemistry, about not-so-usual rearrangement of two important amino acids, together with our favourite NMR specialist Michal Malon. Big congrats to all co-authors!
09/12 – Our colleague Patricia finally returned back from her internship in Canada. Welcome back, we truly missed you! 🙂
04/12 – Sona had her PhD graduation ceremony! Congratulations once again to your success!
29/11 – Mirek traveled a long journey to Canada, to visit one of our collaborators – prof. Tomas Hudlicky – and had there an invited talk about “Shooting with drug-like molecules using solid-phase synthesis”.
25/11 – Sona had presentation about her work at University of Cambridge, UK in the group of prof. David Spring. Magical city with excellent chemistry department, it was simply an honor to be there.
06 – 08/11 – Sona and Mirek attended 54th Advances in Organic, Bioorganic and Pharmaceutical Chemistry “Liblice 2019”, this time in beautiful surroundings of Spindleruv Mlyn, Czech Republic. Sona presented part of her research activities achieved during Ph.D. study and Mirek was honored to be a chairman of one of the scientific sections. It was a great event in every aspect!
04/10 – Patricia is sending greetings from her current scientific heaven at Brock University, Ontario (where she is together with her husband and our colleague Michal) !
01/10 – Two new undergraduate students – Katka and Misa – joined our group. They will work on synthesis and biological evaluation of new potent chronotherapeutics. Welcome!
12/09 –Very happy news! Our dear colleague Sona has successfully defended her thesis and can call herself a doctor from now on (actually, not a real doctor, just a PhD 🙂 🙂 🙂 ). Congratulations to your success!
29/08 – Our colleague Patricia just left for her 3-months internship in Ontario, Canada. She will join a group of prof. Hudlicky at St. Catharines, where she will synthetizing analogs of narciclasin. Enjoy your stay and return back safely!
31/07 – After long and tedious process, the complex review about imidazopyridine-based selective and multifunctional ligands is finally published in Eur. J. Med. Chem.! The paper arose as a result of our collaboration with Jagiellonian University in Kraków, Poland and congratulations mainly go to David, as the first author, who spent quite a lot of time with creating this masterpiece!
20/06 –Sona presented her work at XVIII International Conference on Heterocycles in Bioorganic Chemistry “Bioheterocycles” in beautiful city of Ghent, Belgium and she won the first place for the “Best Oral Communication”! Soural group is decently represented abroad, I must say!
23/05 –Sona presented her work at XIX. Interdisciplinary meeting of young life scientists at Milovy, Czech Republic. She ended in “TOP 5 presentations in chemical sciences”. Congrats!
03/05–Great success for Soural group again! Sona competed in Dean’s award and she won the PhD section as well as the whole chemistry section. Congratulations!
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30/04– David arrived back from his internship, we are so happy to have you here again!
28/03–Sona has been nominated as a representative of Palacky University in Jean-Marie Lehn Prize for Chemistry. Fingers crossed!
28/01 – 30/01– We had spent 3 amazing days at traditional team-building event of our Department at Ski Areal Karlov pod Pradedem!
14/01 – Petra has published new first-autorship paper dealing with synthesis of single and fused diketomorpholines in ACS Comb. Sci. Good job!
17/12– Tremendous ending of this marvelous year! Another first-authorship publication of Sona, dealing with PROTAC conjugates, has been published in Chemical Communication! Congratulations to all authors, great job!
14/12 – Petra returned from her internship in Kraków. Welcome back!
10/12– Our group organized annual pre-Christmas meeting at our department. Lots of snacks, hot wine and music, but mainly great memories.
04/12– New bachelor student Iva joined our group. Feel welcome!
01/06 – Patricia successfully defended her Master thesis and graduated with honours. Congratulations!
03/05 – Soural group totally rocks! Patricia and Sona attended prestigious Dean’s Award at our Faculty and they represented us very well! Patricia won 2nd place in the Master section (Chemistry), whereas Sona conquered the whole competition – 1st place in Ph.D section, 1st place in Chemistry section and overall winner of all sections. Congrats to both of you!
23/04 – Sona finally returned from her internship in Germany. Welcome back!
20/04 – Another pleasant collaboration with our Japanese colleagues, Dr. Michal Malon and Dr. Hiroyuki Koshino, led to new paper about new compounds derived from alfa-acylamino ketones in Molecules. This work belongs to the Special Issue Solid Phase Synthesis.
12/04 – Collaboration with Hlavac group from our department yielded in J. Med.Chem publication. Congratulations to all co-authors!
07/02 – Successful collaboration with Urban group from our department brought another juicy fruit! The fluorescently labeled triterpenes got published in Chem. Eur. J. Thanks to all authors for great work!
06/02 – Patricia published part of her Master thesis in Synlett. Congratulations!
31/01 – Veronika and our Japanese NMR expert Dr. Michal Malon published another joint paper about triethylsilane enantioselective reduction in Eur. J. Org. Chem.
12/01 – Jozef Pecha joined our group for his bachelor thesis. He will work under David’s laboratory supervision. Welcome!
08/01 – Sona left us for a while and started her 5 months internship in Goettingen, Germany in group of prof. Alcarazo. She will be dealing with hypervalent sulphur compounds. Enjoy your stay as much as you can!
22/12 – A short review about applications of triethylsilane in organic synthesis is published in Eur. J. Org. Chem. Congratulations belong to Veronika!
16/12 – Congrats to David for his recent first-autor publication in Eur. J. Med. Chem. Thanks to all authors for collaboration!
10/12 – Our group organized small Christmas party at our department. It was amazing although some memories from the evening are missing…
24/11 – Congrats to Sona for her recent first-author publication about CDK inhibitor conjugates with folic acid in J. Org. Chem. Thanks to all authors for collaboration!
03 – 05/11 – Sona attended 52nd Advances in Organic, Bioorganic and Pharmaceutical Chemistry “Liblice 2017” with short oral presentation.
02/11 – Martina Drabikova published her first author publication about selectivity of Mitsunobu alkylation in Tetrahedron, as a part of her Master thesis. Martina was under supervision of Sona, so it’s huge success for both of them!
19/10 – Congratulation to Petra for her recent publication in ACS Combinatorial Science. We are also thankful to Dr. Michal Malon for his kind help with NMR analysis.
10/10 – Hard work pays off. Sona received prestigious DAAD funding for her upcoming internship in Germany. Congratulations!
30/08 – We attended 17th Blue Danube Symposium on Heterocyclic Chemistry in Linz, Austria. It was one of the best conference so far! Many interesting topics and great memories (“Eldorádo!”) from this beautiful city.
29/4 – First photo of our group!
01/03 – Zuzka Balova and Renata Panikova joined us for their Bachelor theses. Welcome!