October 2025
- 15/10 – In collaboration with Jagiellonian University in Kraków, a new study has been carried out exploring the effects of 5-HT₆ ligands on the gastrointestinal tract. 🧠💊
- 01/10 – Katka has embarked on a three-month research stay at the University of Cambridge in David Spring’s group, where she met our former colleague Soňa Krajčovičová. We’re thrilled that these collaborations continue to flourish, even though Soňa has long since moved on from our group. Soňa shared some lovely news from the UK after her arrival:
“The shining stars from the Soural group have made it all the way to Cambridge 🤣 I’m so happy that Kačka is here! 😁 She’ll be working on the preparation of degrader–antibody conjugates (DACs), which will also form part of her PhD project 😌 So the stay will be truly beneficial for both sides!”
✨ We couldn’t agree more and wishing Katka a successful and inspiring stay in Cambridge!
September 2025
- 26/09 – Simona took part in the Researchers’ Night — thank you for showcasing the magic of organic chemistry to the wider public! 🔬
- 01/09 – We’re excited to welcome our new team members! 🎉 Simona Belošová and Štěpán Kobelka are joining us for their master’s theses, while Matej Rehák is starting his bachelor’s project. Let’s wish them all the best for a great start and excellent results ahead! 💪🧪
July 2025
- 02/07 – Mirek gave a lecture for high school students at the Faculty of Science’s Summer School of Young Researchers, titled “The Magic of Serendipitous Drug Discoveries.” ✨💊
May 2025
- 29/05 – Lukáš Vašinka has successfully defended his master’s thesis. Congratulations, and best of luck at the IOCB in Radim Nencka’s group! 🎓👏
- 22/05 – Taťána Pálová, Matyáš Jirka, and Kristýna Sedláčková have all successfully defended their bachelor’s theses! 🎓 Kristýna is continuing her studies in our department, Táňa has found her path in the master’s programme in Analytical Chemistry, and Matyáš is pursuing Organic Chemistry at Masaryk University in Brno.
- 15/05 – The work of Barča and Kačka about the innovative synthesis of fused isoindoles has been accepted for publication in The Journal of Organic Chemistry, complete with a Supplementary Cover Graphic!
- 05/05 – In the competition for the Dean’s Award for the Best Student Thesis, Táňa claimed a wonderful second place in the Chemistry bachelor’s category. Congratulations, what a fantastic achievement! 🎉
March 2025
- 31/03 – We’re happy to welcome Karolina Babijczuk, a doctoral student from Adam Mickiewicz University in Poznań, who has just joined the group for a short-term internship. Enjoy your stay with us!
- 31/03 – Barča and Kačka rocked their presentations at the departmental seminar. Great job, ladies – exciting results!
- 05/03 – Kačka has been diligently developing a novel synthetic method for BODIPY dyes. The outcome is striking – clearly observable even with basic visual spectroscopy! 😂
February 2025
- 13/02 – We’re excited to share that the results of a collaborative project between the Department of Cell Biology and us – exploring monoterpenoids as ligands of the aryl hydrocarbon receptor – have just been published in Bioorganic Chemistry.
- 11/02 – The International Day of Women and Girls in Science is especially meaningful for our group – we simply couldn’t do what we do without the incredible women on our team! Barča, Kačka, Táňa, Kristýna, and Magda – thank you for your dedication and for doing great science with us!
January 2025
- 26/01 – Kačka helped out at the Open Day event for high school students, where they had the chance to explore our labs and learn more about our study programs as they consider their future paths. Huge thanks for inspiring the next generation to pursue (bio)organic chemistry!
- 21/01 – Lukáš presented his diploma thesis project at the student seminar.
- 09/01 – We are thrilled to share that our previous work on the Truce–Smiles rearrangement as a route to pyridines has been featured in Synfacts! It’s incredibly rewarding to see our research resonating with the chemical community.
December 2024
- 16/12 – Táňa and Kristýna presented their experimental results at the undergraduate research seminar, showcasing excellent progress on their project focused on cytotoxic pyrroloquinolines.
- 15/12 – The Czech Science Foundation has just approved a joint grant application from the Department of Organic Chemistry and the Department of Experimental Biology, focused on inhibitors of oncogenic protein kinases. Our group will contribute through the synthesis of PROTAC degraders. Keep your fingers crossed for a successful outcome!
- 13/12 – Our group Christmas party was amazing as always! 😊 Enjoy this photo of our current group members having fun – we’re looking forward to another exciting and productive year in the lab!
October 2024
- 16/10 – A collaborative project between our group and the Šebela group (Department of Biochemistry), focused on the development of a novel activity assay for diamine oxidase, has just been published in Molecules.
September 2024
- 05/09 – With a new academic year, we are happy to welcome a new cohort of undergraduate students in our group – Štěpán Janoušek, Magda Tománková, and Josef Trtík!
- 04/09 – Berenika’s research project devoted to the synthesis of polysubstituted triazoloquinoxalines was accepted in ACS Omega. Good job, congrats!
August 2024
- 25/08 – Katka’s poster abstract has been accepted and so she will attend the 20th Blue Danube Symposium on Heterocycles in Chemistry in Prague! Thanks a lot for representing our research group!
June 2024
- 04/06 – Katka and Berenika have successfully defended their Master’s theses and graduated with honours! Congratulations to both team members! And we are looking forward to seeing Katka start her PhD in September in our group!
- 14/06 – Katka has been awarded the Talented Student Prize 2024, granted by the Head of the Department. Very well deserved!
March 2024
- 17/03 – Hard work pays off! Katka has published part of her master’s work, which deals with the synthesis of 2-amino indoles, in Adv. Syn. Cat.! Congrats!
November 2023
- 09/11 – We had a really good time this year at the 57th Advances on Organic, Bioorganic, and Pharmaceutical Chemistry “Liblice” Conference in Spindleruv Mlyn! Bara, Katka, and Berenika presented their work in the form of posters and Mirek has been invited to give a lecture. It was also great to see our former colleague Sona, who is now at the University of Cambridge, as she also gave an update on her postdoctoral work there!
October 2023
- 20/10 – Research in the field of tryptamines switching AhR receptors, which we made in collaboration with Dvorak´s group, was accepted in Toxicology Letters. Congratulations!
- 11/10 – Spotted – a new photo of our research group! Thanks to our beloved colleague Honza Pokorny. Meet the Soural group members as of Oct 2023: (top row) Lukas, Petra, Bara, Mirek, Barbora, Tatana, (bottom row) Matyas, Katka, Berenika, and Kristyna.
- 06/10 – Our work on the synthesis of pyridines using the Truce-Smiles rearrangement was highlighted in Organic Chemistry Portal Heteroaromatics: The Zhu Synthesis of Anibamine B (organic-chemistry.org). Thanks a lot for your interest!
September 2023
- 27/09 – New members are coming! Barbora Dopitova, Kristyna Sedlackova, and Tatana Palova have chosen our group for their bachelor work. Welcome!
- 08/09 – Lukas Vasinka will continue to work in our group for his Master’s thesis. Good luck with your project Lukas!
June 2023
- 16/06 – Great news! Michaela Tkadlecova is a laureate of the Talented Student Prize 2023 granted by the Head of the Department – in this case Mirek. 🙂 Well-deserved acknowledgment of your hard work Misa! We are proud of you!
- 06/06 – Lukas Vasinka and Nina Mjartanova have defended their Bc. theses. Congratulations to both team members!
- 05/06 – Hana Katrusakova has defended her Bachelor’s thesis under the supervision of Petra and she decided to continue her research career in the area of Experimental biology. Thank you for your hard work Hanka and good luck with your career!
- 01/06 – Our Misa has defended her Master’s thesis under the supervision of Mirek. Congratulations!
May 2023
- 19/05 – The undergraduate student Duy-Tan Le from Aix Marseille University joined our group for a short internship supported by the Erasmus program. We hope you’ll like it here!
- 11/05 – The work on monoterpenes as AhR antagonists originating from the group of Zdenek Dvorak was accepted in Nature Communications. We are proud to participate in this amazing project!
February 2023
- 07/02 – The work of Michaela and Bara devoted to solid-phase synthesis of unique pyridines or pyrazines from polymer-supported acids was just accepted in JOC! Amazing!
January 2023
- 26/01 – Katerina, Michaela, and Berenika presented their theses at an undergraduate seminar at our Department: thanks for an update on your results!
- 16/01 – New year, new place! After almost 10 years there has come the time to say goodbye and we decided to move our lab from IMTM (Faculty of Medicine) to the Department of Chemistry (Faculty of Science). But no time to be gloomy, we are thrilled and excited about the new opportunities that are waiting there for us! Can’t wait to unpack those boxes and get our hands wet in the lab again! 🙂
December 2022
- 12/12 – Lukáš and Nina presented their theses at an undergraduate seminar at our Department: thanks for an update on your results!
November 2022
- 10/11 – Barča presented her research about new synthetic routes towards pyridines and pyrazines at 56th Advances in Organic, Bioorganic, and Pharmaceutical Chemistry “Liblice” Conference.
September 2022
- 22/09 – Our intensive PROTAC research done by Sona and Eva (Krystof group) has been published in EurJMedChem. Great results of this marvelous collaboration, thanks a lot!
- 04/09 – Petra and Katerina participated in the Czech and Slovak Chemical Society meeting in Olomouc. Thanks for a lecture and a poster!
- 01/09 – A new member of our research group has started her research on the synthesis of triazoloquinoxalines: welcome Berenika and good luck with your thesis!
August 2022
- 28/08 – Mirek has given an invited lecture at the Barrande-Vltava meeting in Dijon. A perfect chance to disseminate the results of our group!
July 2022
- 01/07 – David’s time in our group has sadly come to an end as he starts his new job at Alven Pharmaceuticals. Thank you for your hard work and we wish you the best of luck, you will be missed!
June 2022
- 30/06 –The new synthesis of quinolines developed by Petra and Katerina was just accepted in EJOC. Congratulations!
April 2022
- 13/04 – Solid-phase synthesis of pentasubstitued pyrroles from immobilized aspartate was just accepted in OBC. Congrats Bara!
- 11/04 – New bachelor student Matyas Jirka has joined our research group. His work will be devoted to the synthesis and study of heterocyclic ligands of androgen receptors. Good luck!
March 2022
- 14/03 – Diversity-oriented synthesis of various heterocycles starting from polymer-supported vinylalanine developed by Petra was accepted in JOC. Well done!
September 2021
- 30/09 – Happy to announce the success of our David who won the Special Prize for Chemistry from the Czech Chemical Society in the Jean-Marie Lehn Prize for Chemistry competition! Congratulations, we are proud of you!
July 2021
- 09/07 – Congratulations to Sona for her next first-author paper dealing with gallium-labeled deferoxamine conjugate in collaboration with Dr. Petrik lab (IMTM).
- 01/07 – A very good representation of the Soural group at Students Dean’s Award again! Our bachelor student Michaela won 2nd place in the bachelor chemistry section. We are very proud of you. 🙂
June 2021
- 24/06 – Good things come to those who work hard and never give up! Our colleague Sona has become 2021 fellow of Experientia Foundation and she will continue her postdoctoral training at the University of Cambridge in the group of Prof. David Spring, starting July 2021! All the best and good luck!
- 1/06 – Congratulations to Petra for her new publication in the Journal of Organic Chemistry dealing with the diversity-oriented synthesis of triazolo-diazepine derivatives!
May 2021
- 17–21/05 – Sona attended XX. Interdisciplinary Meeting of Young Life Scientists which usually takes place at Milovy (Czech Republic) but this year has been held online due to the covid-19 pandemic. Nevertheless, it was an interesting event, where she presented her recent work about SYK and BTK protein kinase inhibitors and she has been placed in “TOP 5 presentations in organic chemistry & catalysis”. Congrats!
- 05–06/05 – Amazing week in the Soural group! Congratulations to David, who defended his Ph.D. thesis and became our new doctor! And also congrats Patricia to her RNDr. (Czech equivalent of doctor of science) defense. 🙂 Hopefully, we will celebrate the success when covid will be over!
March 2021
- 11/03 – Sona has been placed 9th (from more than 200 candidates) with her dissertation thesis High-throughput conjugation of drug-like molecules for chemical biology in the prestigious Werner Von Siemens Prize this year! Congratulations on your success 🙂
- 02/03 – Collaboration within our Department bears fruit again! First-authorship paper for Sona dealing with a novel method for preparation of N-substituted 3-hydroxyquinolinones in collaboration with Jan Hlavac group is now online in RSC Advances. Congratulations!
January 2021
- 13/01 – What is the best way to start a new year? Accepted publication in the prestigious Journal of Medicinal Chemistry! Our long-time collaboration with Jagiellonian University in Kraków about imidazopyridine-based 5-HT6 receptor derivatives yielded this perfect piece of work. Congratulations to David for his other first-authored paper. 🙂
December 2020
- 23/12 – Huge success for the Soural group again! The work of Patricia and Bara about copper-free polymer-supported synthesis of triazoles was accepted in Adv. Synth. Catal.! It seems like this year won’t be so bad after all. 🙂
- 16/12 – Hello there after a while! We have some good news to share within the scientific world. It looks like Christmas is coming to Olomouc earlier this year: a very comprehensive and quality study about BTK inhibitors was accepted in Eur. J. Med. Chem. Congratulations to Sona and David! We enjoyed another successful collaboration with our favorite colleagues from LGR very much. 🙂
September 2020
- 30/09 – Another interesting work dealing with chiral oxazepanes is online in RSC Advances. Congratulations to all authors!
- 19/09 – Our collaboration with Jagiellonian University in Kraków (Poland) bears another sweet fruit! The new work about PDE 4 and 7 inhibitory activity is now online in Eur. J. Med. Chem. Congratulations to David, Veronika, and Bara!
August 2020
- 01/08 – Our new work dealing with SYK inhibitors is now online! Good job from our collaborators in the Laboratory of Growth Regulators and congratulations to Sona for her another (joint) first authorship publication!
July 2020
- 08/07 – Another Dean’s Award competition, another Soural group success! David and Petra have presented their work and won 1st and 2nd place, respectively, in the chemistry Ph.D. section. Congratulations to both of you!
March 2020
- 18/03 – Petra has been nominated as a representative of Palacky University in Jean-Marie Lehn Prize for Chemistry. Fingers crossed!
- 11/03 – Since today our undergraduate students are not allowed to work in the lab due to the COVID-19 restrictions. 😦 But health comes first! We hope that the situation will get better soon. Stay home, and study literature. 🙂
January 2020
- 20/01 – 22/01 – The best time of the year is here again! We had spent 3 amazing days at the traditional team-building event of our Department in Ski Areal Karlov pod Pradedem. Amazing weather and great people, as always. 🙂
December 2019
- 16/12 – Another successful collaboration in our group! Petra published her first-authored paper, this time in The Journal of Organic Chemistry, about a not-so-usual rearrangement of two important amino acids, together with our favorite NMR specialist Michal Malon. Congrats to all co-authors!
- 09/12 – Our colleague Patricia finally returned from her internship in Canada. Welcome back, we truly missed you! 🙂
- 04/12 – Sona had her PhD graduation ceremony! Congratulations once again on your success!
November 2019
- 29/11 – Mirek has traveled to Canada, to visit one of our collaborators – prof. Tomas Hudlicky – and had there an invited talk about “Shooting with drug-like molecules using solid-phase synthesis”.
- 25/11 – Sona had a presentation about her work at the University of Cambridge, UK in the group of Prof. David Spring. Magical city with an excellent chemistry department, and it was simply an honor to be there.
- 06 – 08/11 – Sona and Mirek attended 54th Advances in Organic, Bioorganic, and Pharmaceutical Chemistry “Liblice 2019”, this time in the beautiful surroundings of Spindleruv Mlyn, Czech Republic. Sona presented part of her research activities achieved during Ph.D. study and Mirek was honored to be a chairman of one of the scientific sections. It was a great event in every aspect!
October 2019
- 04/10 – Patricia is sending greetings from her current scientific heaven at Brock University, Ontario (where she is together with her husband and our colleague Michal)!
- 01/10 – Two new undergraduate students – Katka and Misa – joined our group. They will work on the synthesis and biological evaluation of new potent chronotherapeutics. Welcome!
September 2019
- 12/09 – Very happy news! Our dear colleague Sona has successfully defended her thesis and can call herself a doctor from now on (actually, not a real doctor, just a PhD 🙂 🙂 🙂 ). Congratulations on your success!
August 2019
- 29/08 – Our colleague Patricia just left for her 3-month internship in Ontario, Canada. She will join a group of Prof. Hudlicky at St. Catharines, where she will synthetize analogs of narciclasin. Enjoy your stay and return back safely!
July 2019
- 31/07 – After a long and tedious process, the complex review about imidazopyridine-based selective and multifunctional ligands is finally published in Eur. J. Med. Chem.! The paper arose as a result of our collaboration with Jagiellonian University in Kraków, Poland and congratulations mainly go to David, the first author, who spent quite a lot of time creating this masterpiece!
June 2019
- 20/06 – Sona presented her work at the XVIII International Conference on Heterocycles in Bioorganic Chemistry “Bioheterocycles” in the beautiful city of Ghent, Belgium and she won first place for the “Best Oral Communication”! Soural group is decently represented abroad, I must say!
May 2019
- 23/05 – Sona presented her work at XIX. Interdisciplinary meeting of young life scientists at Milovy, Czech Republic. She ended in “TOP 5 presentations in chemical sciences”. Congrats!
- 03/05 – Great success for the Soural group again! Sona competed in the Dean’s Award and she won the PhD section as well as the whole chemistry section. Congratulations!
April 2019
- 30/04 – David arrived back from his internship, we are so happy to have you here again!
March 2019
- 28/03 – Sona has been nominated as a representative of Palacky University in Jean-Marie Lehn Prize for Chemistry. Fingers crossed!
February 2019
- 01/02 – David left us for a while and started his 3 months internship in Vienna. He will join the group of Prof. Nuno Maulide. Enjoy your stay!
January 2019
- 28/01 – 30/01 – We spent 3 amazing days at the traditional team-building event of our Department at Ski Areal Karlov pod Pradedem!
- 14/01 – Petra has published a new first-authorship paper dealing with the synthesis of single and fused diketomorpholines in ACS Comb. Sci. Good job!
December 2018
- 17/12 – Tremendous ending to this marvelous year! Another first-authorship publication of Sona, dealing with PROTAC conjugates, has been published in Chemical Communication! Congratulations to all authors, great job!
- 14/12 – Petra returned from her internship in Kraków. Welcome back!
- 10/12 – Our group organized an annual pre-Christmas meeting at our department. Lots of snacks, hot wine, and music, but mainly great memories.
- 04/12 – New bachelor student Iva joined our group. Feel welcome!
November 2018
- 02 – 04/11 – Patricia, Sona, and David attended 53rd Advances in Organic, Bioorganic and Pharmaceutical Chemistry “Liblice 2018” in Lázně Bělohrad, Czech Republic with their posters and Mirek was honored to have an invited lecture, talking about results of the whole squad. Amazing event, I must say!
October 2018
- 31/10 – Spotted. MS group has been photoshooted! Many thanks to our kind and skilled colleague Honza Pokorny for the beautiful photos!
- 04/10 – Veronika Zdrazilova joined our group for her bachelor thesis. Welcome!
September 2018
- 17/09 – Petra left us for a while and started her 3 months internship in Kraków, Poland in a group of Assoc. Prof. Zajdel. Enjoy your stay as much as you can!
- 13/09 – Daniel joined us for his Master thesis. Welcome!
- 09 – 12/09 – Petra attended a local conference 70th Congress of the Czech and Slovak Chemical Societies in Zlin, with short oral communication about her PhD results.
August 2018
- 23 – 25/08 – Mirek attended the Young Investigator Workshop 2018 at the University of Oxford as a plenary speaker.
July 2018
- 23/07 – Patricia started her PhD. May the Force be with you!
- 03/07 – Congrats to Petra for her recent first-author publication in ACS Combinatorial Science.
June 2018
- 01/06 – Patricia successfully defended her Master’s thesis and graduated with honors. Congratulations!
May 2018
- 03/05 – Soural group totally rocks! Patricia and Sona attended the prestigious Dean’s Award at our Faculty and they represented us very well! Patricia won 2nd place in the Master section (Chemistry), whereas Sona conquered the whole competition – 1st place in Ph.D. section, 1st place in the Chemistry section, and overall winner of all sections. Congrats to both of you!
April 2018
- 23/04 – Sona finally returned from her internship in Germany. Welcome back!
- 20/04 – Another pleasant collaboration with our Japanese colleagues, Dr. Michal Malon and Dr. Hiroyuki Koshino, led to a new paper about new compounds derived from alfa-acylamino ketones in Molecules. This work belongs to the Special Issue Solid Phase Synthesis.
- 12/04 – Collaboration with the Hlavac group from our department yielded in J. Med.Chem publication. Congratulations to all co-authors!
February 2018
- 07/02 – Successful collaboration with the Urban group from our department brought another juicy fruit! The fluorescently labeled triterpenes were published in Chem. Eur. J. Thanks to all authors for their great work!
- 06/02 – Patricia published part of her Master’s thesis in Synlett. Congratulations!
January 2018
- 31/01 – Veronika and our Japanese NMR expert Dr. Michal Malon published another joint paper about triethylsilane enantioselective reduction in Eur. J. Org. Chem.
- 12/01 – Jozef Pecha joined our group for his bachelor thesis. He will work under David’s laboratory supervision. Welcome!
- 08/01 – Sona left us for a while and started her 5-month internship in Goettingen, Germany in a group of Prof. Alcarazo. She will be dealing with hypervalent sulfur compounds. Enjoy your stay as much as you can!
December 2017
- 22/12 – A short review about applications of triethylsilane in organic synthesis is published in Eur. J. Org. Chem. Congratulations belong to Veronika!
- 16/12 – Congrats to David for his recent first-author publication in Eur. J. Med. Chem. Thanks to all authors for your collaboration!
- 10/12 – Our group organized a small Christmas party at our department. It was amazing although some memories from the evening are missing…
November 2017
- 24/11 – Congrats to Sona for her recent first-author publication about CDK inhibitor conjugates with folic acid in J. Org. Chem. Thanks to all authors for your collaboration!
- 03 – 05/11 – Sona attended 52nd Advances in Organic, Bioorganic and Pharmaceutical Chemistry “Liblice 2017” with a short oral presentation.
- 02/11 – Martina Drabikova published her first author publication about the selectivity of Mitsunobu alkylation in Tetrahedron, as a part of her Master’s thesis. Martina was under the supervision of Sona, so it was a huge success for both of them!
October 2017
- 19/10 – Congratulations to Petra for her recent publication in ACS Combinatorial Science. We are also thankful to Dr. Michal Malon for his kind help with NMR analysis.
- 10/10 – Hard work pays off. Sona received prestigious DAAD funding for her upcoming internship in Germany. Congratulations!
August 2017
- 30/08 – We attended 17th Blue Danube Symposium on Heterocyclic Chemistry in Linz, Austria. It was one of the best conferences so far! Many interesting topics and great memories (“Eldorádo!”) from this beautiful city.
April 2017
- 29/4 – First photo of our group!
Soural group 